As a first step towards discovery of genes expressed from only one allele in the CNS, we used a tiling array assay for DNA sequences that are both methylated and unmethylated (the MAUD assay).We analyzed regulatory regions of the entire mouse brain transcriptome, and found that approximately 10% of the genes assayed showed dual DNA methylation patt
Application of aluminium alloys for military purposes
Owing to their strength-to-weight ratio, plasticity, fracture toughness and corrosion resistance, aluminium alloys are widely applied in military industry.New technologies and intensive activity in this field enabled replacement of steel parts here by aluminium alloys in development and production of modern fighting vehicles, missiles and ammunitio
Results from the CLUES study: a cluster randomized trial for the evaluation of cardiovascular guideline implementation in primary care in Spain
Abstract Background The implementation of evidence-based clinical practice guidelines (CPG) can improve patients care.To date, the impact of implementation strategies has not been evaluated in our context.This study is aimed to evaluate the effectiveness of a multifaceted tailored intervention targeting clinician education for the implementation of